A comprehensive multi-cohort survey of publicly available transcriptomic data from normal, primary and metastatic prostate tissues highlights the role of Myc, alpha-methylacyl-CoA racemase (AMACR) and glutathione S-transferase P (GSTP) in tumor initiation, and of AR, EZH2, steroid 5a-reductase (SRD5A), tumor protein TP63, centromere protein A (CENPA) and PI3K catalytic subunit b (PIK3CB) in tumor progression [160]. This evidence concerns the gene EZH2 and neoplasm.