It should be noted that although six different types of GLUT are expressed in the placenta, including GLUT4, insulin-independent GLUT1 is the most abundant isoform, and is therefore considered to be the main responsible for the maternal-fetal glucose exchange [109], so it is likely that the placental effects of these adipokines are not directly related to insulin resistance. This evidence concerns the gene SLC2A4 and Insulin resistance.