On the other hand, more studies longitudinally assessing the maternal levels of IL-8, IL-10, IFN-γ, adipsin, NGAL, NGF, MCP-1, omentin-1, FABP4, chemerin, sOB-R, vaspin, RBP-4, visfatin, PAI-1, ANGPTL8, nesfatin-1, DLK1, fetuin A, fetuin B, and AFABP are needed to have a better understanding of their pathophysiological roles in GDM. The gene discussed is LCN2; the disease is gestational diabetes.