In experiments with TNFRI−/− mice, TNFRI knockout failed to prevent diethylnitrosamine (DEN)-induced HCC, but did suppress development of HFD-promoted DEN-induced HCC, lymphotoxin α/β-overexpression-induced HCC, and hepatocyte-specific TGF-β-activated kinase 1 (TAK1)-deletion-induced HCC [54,86,87,88]. The gene discussed is TNFRSF1A; the disease is hepatocellular carcinoma.