Ras/MAPK, Wnt/b-catenin, TGF-β/Smad, and Rho/actin pathways act together to influence other complex networks of interactions enhancing tumor cell proliferation, differentiation, epithelial-to-mesenchymal transition, and tumor invasiveness [147,148,149,150,151]. The gene discussed is TGFB1; the disease is neoplasm.