BRCA2 and breast cancer: Several risk factors are associated with BC [6], including a family history of BC, due to inherited variants of cancer predisposing genes, such as BRCA1 and BRCA2 [7], early menarche and late menopause [8], obesity [9,10], alcohol consumption [11], physical inactivity [12] and exposure to exogenous hormones (e.g., oral contraceptives and menopausal hormone replacement therapy, [13]).