The first demonstrates that overexpression of LOX or LOXL2 enhances the invasion of breast cancer cells in in vitro invasion assays [9], and the second shows that overexpression of LOXL2 in breast cancer cells increases their invasiveness in a breast cancer mouse tumor progression model, and induces desmoplasia and the deposition of thick collagen bundles in tumors containing cells that strongly express LOXL2 (Figure 2) [10]. This evidence concerns the gene LOXL2 and breast cancer.