One example is the ligand triantennary N-acetylgalactosamine (GalNAc), developed by Ionis Pharmaceuticals Inc., that has high affinity for the asialoglycoprotein receptor (ASGP-R), which is overexpressed in hepatocellular carcinoma cells (HCC) [4]. The gene discussed is ASGR1; the disease is hepatocellular carcinoma.