In head and neck squamous cell carcinoma, Notch signaling is similarly implicated in enhancing EMT-mediated cancer plasticity [67], while in esophageal squamous cell carcinoma, NOTCH3 conversely reduces EMT, with a blockade of Notch promoting expression of mesenchymal markers in esophageal squamous cell carcinoma cell lines [68]. Here, NOTCH3 is linked to esophageal squamous cell carcinoma.