Moreover, amyloidogenesis, an important pathogenetic factor for AD, is strictly associated with lipid composition within membrane lipid rafts, which are characterized by a combination of sphingolipids, cholesterol, saturated FAs, and a reduced content of PUFAs that serve as platforms for β-amyloid (Aβ) interactions with ApoE and tau to promote the aggregation of Aβ oligomers and hyperphosphorylation [11]. Here, MAPT is linked to Alzheimer disease.