In carefully matched T2DM patients, serum interleukin-6, a classical inflammatory marker, did not differ between depressed and non-depressed patients, nor was it associated with depressive symptoms, although CYP450-sEH metabolites were, suggesting that systemically, depression may be associated with an insufficient pro-resolving lipid response rather than inflammation per se [82]. Here, EPHX2 is linked to major depressive disorder.