Sustained hyperglycemia has been shown to increase sEH expression in cerebral vessels in a high fat diet, streptozotocin and nicotinamide (HFD+STZ/NA) mice model of T2DM [58], where the enzymes may contribute to ischemic injury by limiting production of neuroprotective epoxides in the brain. Here, EPHX2 is linked to type 2 diabetes mellitus.