Additionally, sEH inhibition decreased urinary albumin-to-creatinine ratio and increased renal levels of NFκB inhibitor IκB in HFD mice model of diabetic nephropathy, resulting in reduced mRNA expression of renal inflammatory markers monocyte chemoattractant protein-1 (MCP-1), COX2 and vascular cell adhesion protein 1 (VCAM-1) [21]. Here, EPHX2 is linked to diabetic kidney disease.