EPHX2 and diabetes mellitus: Wagner et al. found that administering DHA-derived EpDPEs, sEH inhibitor TPPU (1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea), or a combination of EpDPEs and TPPU alleviated neuropathic pain in a STZ-induced diabetic mouse model [26].