Administering an sEH inhibitor reduced hyperglycemia-induced p38 phosphorylation in a HFD-T2DM mice model [50] and maintained cardiac myocyte morphology and calcium cycling in the University of California Davis (UCD)-T2DM model, processes which are otherwise dysregulated in diabetic cardiomyopathy [54]. Here, EPHX2 is linked to Hyperglycemia.