PINK1 and Hyperglycemia: Decreased renal levels of autophagy proteins, such as lysosomal-associated membrane protein 2 (Lamp2), autophagy-related gene 5 (Atg5), PTEN-induced putative kinase 1 (PINK1) and Parkin, have been reported in mice with HFD/STZ-induced hyperglycemia [43] p62 protein, a selective substrate of autophagy, was also upregulated in this model.