Therefore, to fill the existing gaps in knowledge, our study aimed to examine NCL mRNA and protein expression in tissue samples from pre-menopausal and post-menopausal (PM) healthy endometrium, precancerous endometrial hyperplasia (EH), and all subtypes of EC, including endometrioid, serous, carcinosarcoma and clear cell subtypes, as well as metastatic lesions, thereby comprehensively examining differential levels of NCL in endometrial carcinogenesis. Here, NUCLEOLIN is linked to carcinosarcoma.