MAPT and supranuclear palsy, progressive, 1: The pathological transition of tau from its soluble and monomeric state to its hyperphosphorylated, insoluble and filamentous state will lead to tau dysfunction and occur in many neurodegenerative diseases, such as Alzheimer Disease (AD), Progressive Supranuclear Palsy (PSP), Corticobasal Syndrome (CBS) and so on [2,3,142].