Efflux pumps, the active transporters on cell surface, pump out the drugs from the cells through the production of p-glycoprotein [1] while multidrug resistance-associated protein 1, multidrug resistance protein 1 and breast cancer resistance protein are examples of transporters that also mediate drug resistance in many different cancers, with tyrosine kinase inhibitors (TKIs) being their well-known targets [10]. The gene discussed is ABCB1; the disease is cancer.