Single-cell RNA-seq of ascites samples from high-grade serous ovarian carcinoma (HGSOC) patients revealed subpopulations of CAFs expressing immune-related genes that were categorized as complement factors (C1QA/B/C, CFB), chemokines (CXCL1/2/10/12) and cytokines (IL6 and IL10), which are responsible for the activation of JAK/STAT signaling in tumor cells. The gene discussed is CXCL1; the disease is neoplasm.