RNA sequencing of TAMs isolated from the ascites of patients with HGSOC demonstrated that CD163+ or CD206+ macrophages displayed increased expression of pro-tumor growth factors and cytokines, such as CCL18, KITLG, SEMA6B, S100B and VEGFB, and tumor suppressive mediators, e.g., CXCL10, CXCL11, IL15, TNFSF10 and TNFSF14 [97]. This evidence concerns the gene SEMA6B and neoplasm.