In turn, CAFs activated by ITGA5-overexpressing tumor cells secrete TGFβ-associated factors EGF, IP-10, IGFBP-3, BDNF, Flt-3 LG, FGF-7, IL-12, MIF and leptin (Figure 1B) [69]. The gene discussed is TGFB1; the disease is neoplasm.