PRKAA2 and pulmonary hypertension: Similarly, another study showed that both the activity and expression levels of AMPK were decreased in PAECs in mice with pulmonary hypertension induced by fetal ductus arteriosus constriction; in this case, the decrease in AMPK was attributed to increased expression of protein phosphatase 2A (PP2A) and protein phosphatase 2C (PP2C), and AMPK activation ameliorated PAH [148].