Moreover, BCA treatment led to increased nuclear translocation of the FOXO3 transcription factor, due to impaired DNA reparation and increased ROS generation, thus, suggesting ROS accumulation and FOXO3 transcriptional program activation as possible mediators of BCA-induced apoptosis in RCC cell lines, as shown in Figure 2 [45]. This evidence concerns the gene FOXO3 and renal cell adenocarcinoma.