Not only are p53 mutations an infrequent event in RCC, but many of the proteins involved in the regulation of apoptosis, such as Puma, Bax, and the Bcl-2 family, are not mutated or dysregulated at an mRNA level in cohorts of patients from cancer databases, such as the Firehose legacy from the TCGA (cbioportal.com accessed on 15 February 2022), Figure 1. The gene discussed is TP53; the disease is renal cell carcinoma.