Moreover, necroptosis can be re-activated in RCC by the inhibition of the NF-κB signaling, which is partially obtained by the use of the proteasome inhibitor PS-341; this inhibition leads to IFN-γ triggered necroptosis through JAK1/2 and STAT1 signaling [170]. This evidence concerns the gene NFKB1 and renal cell carcinoma.