CCL2 and rheumatoid arthritis: These low levels are related to augmenting inflammation and OS in RA via modulation of specific immune-inflammatory, necroptotic molecular, and biochemical pathways, such as the high-mobility group protein box 1 (HMGB1)/monocyte chemoattractant protein 1 (MCP1)/chitotriosidase I–mediated necroptosis.