Then, we constructed a prognostic index for all PC individuals calculated by the formula PRGPI risk score = 0.2688 × expression of AIM2 + 0.2244 × expression of GBP1 + 0.3797 × expression of HMGB1 + 0.3468 × expression of IL18 + 0.1764 × expression of IRF6 + 0.0820 × expression of NEK7 + (−0.2797) × expression of NLRP1 + (−0.8197) × expression of PLCG1. The gene discussed is HMGB1; the disease is pachyonychia congenita.