This study revealed a novel mechanism whereby AHR activation as well as CYP1s enzymes can impact cancer progression through the accumulation of oxylipins, particularly epoxides, which confirms the benefits of a high ω-3 PUFA diet and the risk of a high ω-6 PUFAs diet in promoting tumor growth and metastasis in a lung cancer model [20]. Here, AHR is linked to lung carcinoma.