These findings, therefore, reveal a novel mechanism whereby the oxylipins, particularly epoxides generated from ω-3 PUFAs by the TCDD/AHR/CYP1s/sEH pathway protect against tumor growth and metastasis, while ω-6 oxylipins induce the opposite result, through affecting vascularity, cell proliferation and/or apoptosis [20]. The gene discussed is AHR; the disease is neoplasm.