Butylidenephthalide, among the major compounds derived from Angelica sinensis, has been reported to exert an anti-angiogenic activity by suppressing the WD repeat and SOCS box-containing protein 1 (WSB-1)/von Hippel–Lindau (pVHL)/hypoxia-inducible factor-1α (HIF-1α)/vascular endothelial growth factor (VEGF) signaling axis in bladder cancer in vitro and in vivo [16]. This evidence concerns the gene WSB1 and urinary bladder carcinoma.