As for oral cancer, a derivative of n-butylidenephthalide, (Z)-N-(2-(dimethylamino)ethyl)-2-(3-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)phenoxy)acetamide (PCH4), has been found to induce oral cancer cell apoptosis via the enhancement of nuclear receptor 4A1 (Nur77) translocation from the nucleus to the cytoplasm [34]. The gene discussed is NR4A1; the disease is lip and oral cavity carcinoma.