The ongoing BIOmarkers of MIGrAine based on the stratification of responders to CGRP monoclonal antibodies (BIOMIGA) proof of concept study (NCT04503083) includes the assessment of DNA methylation levels in migraine subjects as compared to non-migraineur controls (https://clinicaltrials.gov/ct2/show/record/NCT04503083, accessed on 10 May 2022). Here, CALCA is linked to migraine disorder.