The carriers of the E3/4 genotype had higher triglycerides and LDL-C and lower HDL-C levels, suggesting that the E3/4 genotype is a potential risk factor for AD in T2DM [74] Although ApoE E3/4 or E4/4 alleles were most common in dementia patients with T2DM, the association was significant when the E3/4 genotype was combined with hemochromatosis-HFE gene mutations (H63D and C282Y) in females and with prior cerebrovascular events in males [75]. Here, APOE is linked to Alzheimer disease.