IAPP and Alzheimer disease: A retrospective autopsy-based study reported cytoplasmic depositions of tau and Aβ proteins in pancreatic β cells, and amylin aggregation in the hippocampus of subjects with AD and subjects with normal cognition but a history of T2DM; interestingly, the amylin was found to be colocalized with tau or Aβ in pancreatic and brain tissue [120].