Proinflammatory cytokines such as tumor necrosis factor (TNF), IL-1, IL-2, and IL-6 are overexpressed in diabetes and Alzheimer’s disease patients’ brains [94], indicating the role of inflammation in neuronal damage, likely through the downregulation of the pro-inflammatory microglial function [95]. This evidence concerns the gene TNF and early-onset autosomal dominant Alzheimer disease.