Insulin resistance is one of the multifactorial mechanisms in DM etiology, and various miRNAs, such as miR-320, miR-128a, miR-29, miR-384-5p, miR-143, miR-383, miR-33a/b and miR-133a/b, are reported to target the genes of the main proteins in the insulin signaling pathway and to play a crucial role in developing insulin resistance in adipose tissues [198]. This evidence concerns the gene INS and Insulin resistance.