Interestingly, in animal models, the over-expression of BDNF was shown to improve glucose metabolism and alleviate insulin resistance [167] by suppressing the hyperglycemia-induced neuroinflammation in the hippocampus of type 1 diabetes mice through blocking the HMGB1/RAGE/NF-κB signaling pathway [168]. This evidence concerns the gene NFKB1 and Hyperglycemia.