AGER and diabetes mellitus: Furthermore, a cross-sectional investigation of 167 diabetes participants revealed that serum AGE levels were raised in MCI subjects, and this rise was inversely connected with global cognitive performance and associated with a 72% increase in MCI risk in T2DM patients; however, serum soluble RAGE concentration decreased in diabetes patients with MCI, and an increase in the RAGE level was associated with a 54% reduction in disease risk [16].