TNF and fibromyalgia: In order to investigate the effects of TNF-α inhibitors, etanercept and infliximab, on fibromyalgia, rats were subcutaneously injected with reserpine 1 mg/kg for 3 consecutive days and were intraperitoneally injected with etanercept (3 mg/kg) or infliximab (10 mg/kg) after the last reserpine injection and 5 days after that (Figure 1).