In Mecp2-null mice, the lncRNAs AK081227 and AK087060 were found to be upregulated and the increased levels of AK081227 subsequently caused downregulation of its host coding protein gene, the GABA-receptor subunit RHO2 (GABRR2), adding further complexity to the mechanistic role of MECP2 in Rett syndrome [118]. This evidence concerns the gene MECP2 and Rett syndrome.