Importantly, these stromal cell populations secrete type 1 interferon(s) in response to B cell secretion of lymphotoxin, promoting rise of IFN-signatures for autoimmune diseases such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and Sjögren’s syndrome (SS) [6,79]. This evidence concerns the gene IFNA1 and systemic lupus erythematosus.