If changes in Rlip contribute to neurodegenerative or cognitive disorders in human patients it would likely be due to epigenetic changes in the regulation of Rlip (histone modifications or promoter methylation), altered expression of Rlip-regulating transcription factors or micro-RNAs, or possibly mutations in one of Rlip’s many interaction partners, rather than coding mutations in the RALBP1 gene itself. The gene discussed is RALBP1; the disease is Cognitive impairment.