BACHD mice (12-month-old) presented no changes in their serum levels of cytokines [37], and the quantification of protein levels in blood from 8-week-old R6/2 mice showed no increase in cytokine levels; however, at 14 weeks old, the IL-6, IL-8, IL-1β and TNF-α levels in R6/2 mice were elevated in the same way as anti-inflammatory cytokines IL-2 and IL-10 [38], which correlates with HD disease severity [39]. This evidence concerns the gene IL6 and Huntington disease.