Dengue virus ADE depends on activating FcγRs like FcγRIIa and FcγRIIIa, whereas ADE mediated by SARS-CoV mAbs is dependent primarily on the inhibitory FcγRIIb, and has been shown to cause preferential infection of B cell (cell lines) in vitro [75,105]. The gene discussed is FCGR2B; the disease is infection.