FCGR2A and dengue disease: In addition, abrogation of the Fc–FcγR binding resulted in diminishing the pathogenic activity of these antibodies [81], and patients with symptomatic Dengue virus infection possess elevated serum levels of Fc glycoforms, with improved affinity for FcγRIIIa [82], and increased allelic frequency affinity single nucleotide polymorphism (SNP) of FcγRIIa [83].