SH3GLB1 and cancer: Nevertheless, the absence of Beclin 1 activators such as the UV radiation resistance-associated gene protein (UVRAG) or Bax-interacting factor 1 (Bif-1) has been associated with colon and gastric cancer development, respectively, reinforcing the idea that autophagy regulation by Beclin 1 might be a key step in some cases of cancer development [56,66,67].