CCN2 and pulmonary fibrosis: Depending upon the microenvironment condition and cell type, CTGF is involved in several pathologic processes such as carcinogenesis and tumor development [22], diabetes [23], neuromuscular disorders [24,25], systemic sclerosis [26], ocular diseases [27], cardiac fibrosis [28,29], renal fibrosis [30], liver fibrosis [31], and lung fibrosis [32].