NOTCH1 and cancer: Indeed, with regards to CRC, several genes, such as epidermal growth factor receptor (EGFR), c-Fos, c-Myc, RAS family, Notch-1, transforming growth factor receptor (TGFBR) 1, and TGFBR2, have been identified as crucial regulators involved in the proliferation and invasion processes of these specific cancer cells [49].