For instance, significant pairwise correlations have been found between some cytokines (TNF, IL-1β, IL-6, IL-8, IL-9, IL-10 or vascular endothelial growth factor [VEGF]) and between inflammatory markers, such as neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio or fibrinogen in CRC patients, and those data, associated with tumor staging, could provide predictive information for CRC therapeutic management [41]. This evidence concerns the gene IL6 and neoplasm.