TP53 and cancer: In the context of CRC, RSV exhibited the ability to interfere with the signaling pathways involved in the initiation and progression of this cancer, including silent mating type information regulator two homolog 1 (SIRT1), P53, P21, AMP-activated protein kinase (AMPK), reactive oxygen species (ROS), cyclooxygenase (COX) 2, nitric oxide (NO), caspases, wingless-related integration site (Wnt), TNFs, and nuclear factor kappa-light-chain-enhancer of activated B cell (NF-κB) signaling [70].