Considering the ability of macrophages to respond to different environmental cues, and bearing in mind their crucial role in the context of cancer and specifically CRC, we wanted to assess if the medicine could modulate the cytokine expression profile of macrophages under standard conditions and under different stimuli (20 ng/mL of IFN-γ, 5 ng/mL of IL-4, or 20 ng/mL IL-10), leading to distinct functional macrophages phenotypes, M1, M2a or M2c, respectively. This evidence concerns the gene IL10 and cancer.