Similar observations have been reported in cohort studies where relevant biochemical parameters have been monitored for the study of the development of insulin resistance and diabetes in obese patients, finding that patients with insulin-sensitive obesity have higher levels of adiponectin compared to those with resistance, in addition to patients without obesity, but with insulin resistance have low levels of adiponectin [92]. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.