AGT and obesity due to melanocortin 4 receptor deficiency: For example, there is evidence indicating that under obesity, the local adipose RAS tissue, particularly white visceral adipose tissue (VAT), is increased in humans and animals and clearly correlates with elevated local and systemic Ang II levels, which promotes hypertrophic adipose tissue because of lipid accumulation, adipocyte growth, and differentiation which in turn secrete adipokines [28].