IDH1 and central nervous system cancer: According to the 2016 WHO classification [2], the 97 glioma samples were classified as follows: 11 Grade II, isocitrate dehydrogenase 1/2 (IDH)-mutant and 1p19q-codeleted oligodendrogliomas (O); 16 Grade III, IDH-mutant and 1p19q-codeleted anaplastic oligodendrogliomas (AO); 18 Grade II, diffuse and IDH-mutant astrocytomas (A-IDHMUT); 7 Grade III, IDH-mutant anaplastic astrocytomas (AA-IDHMUT); 8 Grade IV, IDH-mutant glioblastomas (GB-IDHMUT); 37 Grade IV, IDH-wild-type glioblastomas (GB-IDHWT) (Table S1).