Such results could explain why IDHWT glioma are more aggressive tumors with a higher microvascular proliferation than IDHMUT glioma; indeed, the mir-128-3p is a tumor suppressor [37] and both the mir-128-3p and the mir-221-5p sometimes display anti-angiogenic behavior by targeting, in particular, VEGFC [38] and the Hypoxia-inducible factor 1 alpha, respectively [39]. This evidence concerns the gene HIF1A and central nervous system cancer.