NLRP3 and Ureteral obstruction: BM-MSCs were found to suppress the high-salt-induced assembly and activation of NLRP3 inflammasomes (including NLRP3 and caspase 1) and the downstream production of IL-1β in Dahl salt-sensitive rats and 1K/DOCA/salt-injured mice and inhibit innate (macrophages) and adaptive immune (T cells) components in a murine model of fibrotic nephropathy induced by unilateral ureteral obstruction (UUO) [71] and 1K/DOCA/salt-induced hypertensive mice [72,78].