Klotho, a factor produced by the renal tubular epithelial cells with numerous effects that include protecting the heart against stress-induced cardiac hypertrophy and remodeling, was not different in ARB, TRX or Control groups at sacrifice (Control 17.2 ± 4.18, ARB 16.5 ± 2.55, TRX 12.0 ± 2.58 ng/mL) [17]. Here, KL is linked to cardiac hypertrophy.