TIMP2 and intervertebral disk degenerative disorder: MiR-185-5p has been found to protect against excessive extracellular matrix degradation associated with inflammation and degeneration in human IDD samples: indeed, here, the higher expression of a circular RNA derived from tissue inhibitor of metallopeptidases 2 (circ-TIMP2) led to the sequestration of miR-185-5p and the consequent upregulation of miR-185-5p target genes, including MMP-2, associated with extracellular matrix catabolism [95].