Similar to the situation in cutaneous melanoma [122,123], miRNAs and epigenetic mechanisms are involved in MITF regulation in UM cells: miR-137 through downregulation of MITF, MET, and CDK6 (cyclin dependent kinase 6) and miR-182 through inhibition of MITF, MET, BCL2, and cyclin D2, causing G1 cell cycle arrest, thereby reducing the number of metabolically-active UM cells [179,180]. This evidence concerns the gene CDK6 and cutaneous melanoma.