MAPT and Alzheimer disease: Although the key pathological features of AD in the STZ model, such as neuroinflammation, oxidative stress, accumulation of phosphorylated tau and Aβ peptide, and synaptic damage in animal brains, leading to behavioral changes, point to its importance in translational research [19,20], when we consider the respiratory studies available to date, the differences between the studies presented are not consensual.