However, recent work using the C3HeB/FeJ mouse strain that carries the Nramp1 resistant allele demonstrated that aerosol infection with M.av (strain 2285) resulted in chronic progressive lung infection and the formation of necrotic granulomas unlike those seen in other standard inbred mouse strains [22], indicating that the NRAMP1 mediated resistance mechanism is not sufficient to prevent the necrotization of M.av granulomas in that model. This evidence concerns the gene SLC11A1 and Granuloma.