We selected miRNAs for this analysis that met three primary criteria: (i) a predicted in silico interaction with ESR1 or ESR2 mRNA, (ii) a suggested role in the regulation of ESR1 or ESR2 expression in vivo, and (iii) an altered expression in adipose tissue in the course of obesity or weight loss. The gene discussed is ESR1; the disease is obesity due to melanocortin 4 receptor deficiency.