Moreover, further stratification of the female patients by menopausal status revealed that the association between the ESR1 mRNA levels in SAT and diabetes was limited to the premenopausal women only (p = 0.0012, Figure 4e), while in the postmenopausal group, as in the men, no difference between the diabetic and nondiabetic patients was observed (Figure 4d). Here, ESR1 is linked to diabetes mellitus.