ESR1 and metabolic syndrome: Recently, Zhou et al. reanalyzed data from three trials evaluating the correlation between adiposity and ESR1 mRNA levels in SAT biopsies of 766 women (median age 62, ~75% postmenopausal, participants of the TwinsUK study); 24 male participants of the Skeletal Muscles, Myokines, and Glucose Metabolism (MyoGlu) study; and 770 men enrolled in the Metabolic Syndrome in Men (METSIM) study [32,33,34,35].