The AD mediator genes, including PSEN1, PSEN2, and BACE, have abnormal expressions in the HSV-1 infected-cerebral organoids at D42 + 3 and D65 + 3; both RBV and VCV effectively revised the HSV-1-induced changes of AD mediators (Figure 5A–C). The gene discussed is BACE1; the disease is Alzheimer disease.