Clinical and gene expression data from 219 GBMs, 225 low-grade tumors, primary tumors, and 28 normal specimens were used to correlate SHPK mRNA expression levels with histopathological features through the Rembrandt dataset [22] via GlioVis, a web-based data visualization and analysis application for exploring brain tumor expression datasets [23]. This evidence concerns the gene SHPK and brain neoplasm.