For women who experience severe discomfort from adenomyosis, non-steroidal anti-inflammatory drugs and hormone therapy including progestin, oral contraceptive pills, or gonadotropin-releasing hormone (GnRH) agonists can relieve the pain and menorrhagia associated with adenomyosis to prevent the need for hysterectomy, which is the only curative treatment. This evidence concerns the gene GNRH1 and adenomyosis.