TLR4 and cancer: Elevated levels of macrophage markers, such as toll-like receptors 4 (TLR4) [19] CR4, EGF-like module-like mucin receptor-like hormone 1 (EMR1), immune complexes/TLR ligands [20], IL-10, adipose inflammatory cytokine [21], and decreased level of microRNA (miR)-130a, are evidence of the presence of cancer due to excessive HFD intake [22].