Excessive inflammatory responses induced by viral infections are not restricted to the lung but can be systemic, as found for Ebola virus (EBOV) disease and severe dengue fever [166,167,168,169,170,171] The Ebola virus glycoprotein was demonstrated to activate the innate immune response in vivo via TLR4 activation, accompanied by multiple cytokine and chemokine expression, which could be inhibited by TLR4 antagonists [172] and was accompanied by pronounced NF-κB activation [173]. This evidence concerns the gene TLR4 and dengue disease.