Despite modeling and binding data suggesting that the B.1.1.529 spike can bind more avidly to murine ACE2, the authors observed attenuation of infection in three different mouse models, i.e., 129, C57BL/6, and BALB/c mice, as compared with previous SARS-CoV-2 variants, with limited weight loss and lower viral burden in the upper and lower respiratory tracts [7]. The gene discussed is ACE2; the disease is infection.