MYD88 and COVID-19: To determine whether MyD88 or another TLR adapter TRIF (TIR-domain-containing adapter-inducing interferon-β) play a role in SARS-CoV-2-induced inflammatory responses and pathogenesis, a publicly available dataset [147] was analyzed for MyD88 and TRIF expression in patients with differing severities of COVID-19 and showed a positive correlation between MyD88 expression and severity of COVID-19, suggesting that MyD88 is associated with COVID-19 pathogenesis in humans.