ACE2 and infection: Between the S1 and S2 subunits, there is a polybasic PRRAR furin-like cleavage site which is unique to the S protein of SARS-CoV-2 and may, together with the particularly high-binding affinity to the target receptor ACE2 and the peculiarity of a long symptom-free but nevertheless highly infectious time period between infection and appearance of first symptoms or asymptomatic transmission [20], be responsible for the particularly efficient spread of SARS-CoV-2 compared to previous pathogenic hCoVs.