Katayama and colleagues demonstrated that the inappropriate expression of the MECOM gene in AML with 3q-rearrangement was induced by the recruitment of a GATA2-distal hematopoietic enhancer (G2DHE) to the proximity of the MECOM gene, which subsequently disturbed the function of an allele of the endothelial transcription factor GATA-2 (GATA2) gene [45]. This evidence concerns the gene MECOM and acute myeloid leukemia.