The pathogenic fusion of RUNX1 with its partner transcriptional co-repressor 1 (RUNX1T1), previously known as eight twenty one (ETO), plays a critical role in the leukemogenesis of CBF-AML via the aberrant transcription factors that contain oncogenic RUNX1-RUNX1T1 or AML1-ETO, fusion proteins [84]. Here, RUNX1 is linked to acute myeloid leukemia.