NOS1 and cerebral malaria: The dysfunction of NOS is also related to the reduction of NO bioavailability in malaria, as in Ong et al. [100], who assessed the cerebrovascular capacity and the function of NOS isoforms in cerebral malaria in animals; the loss of eNOS and NOS-I isoforms functionality contributes to cerebrovascular injury, which is characterized by vascular constriction, impaired perfusion, and reduced cerebral blood flow, requiring the recovery of enzymes to increase NO bioavailability.