According to Borges et al. [55], the expression of eicosanoid-producing enzymes in mice sensitive to cerebral malaria increases the expression of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) in the vessels and brain tissue, followed by high levels of the transcriptional regulators of lipid metabolism, peroxisome proliferator-activated receptor gamma (PPAR-γ), which results in increased parasitemia, reduced survival, and less NO and H2O2 production in those animals. The gene discussed is PTGS2; the disease is cerebral malaria.