A thorough analysis of the supermere component shows protein enrichment in different diseases ranging from the amyloid precursor protein (APP) and amyloid beta precursor like protein 2 (APLP2) in Alzheimer’s disease; angiotensin I converting enzyme (ACE), ACE2, and proprotein convertase subtilisin/kexin type 9 (PCSK9) in both cardiovascular and COVID-19; argonaute-2 (AGO2), cellular–mesenchymal–epithelial transition factor (MET), and TGFBI in cancers [120]. Here, APLP2 is linked to early-onset autosomal dominant Alzheimer disease.