Among them, LXRα maintains intracellular cholesterol homeostasis by regulating the uptake and excretion of cholesterol, which is essential for glioma proliferation and invasion [87], and HIVEP2 is a transcription factor whose downstream target SSTR2 can inhibit gliomas and also has a regulatory effect on MYC, NF-κB, and TGF-β signaling pathways [85]. This evidence concerns the gene NFKB1 and central nervous system cancer.