PMEL and melanoma: Melan A/MART-1 is a melanoma-associated antigen that is recognized by autologous cytotoxic T lymphocytes, encoded by the MLANA gene located on chromosome 9p24.1, and involved in the formation and trafficking of melanosomes (specifically, of the melanocyte protein PMEL17, which is the antigen recognized by HMB45 and involved in the formation of stage II melanosomes) [57].