SOX10 is a protein of 466 amino acids (about 58 kd), which are normally expressed by melanocytes, Schwann cells in peripheral nerves, oligodendrocytes, and myoepithelial cells, whose genetic mutations is associated with Waardenburg–Shah syndrome (hypopigmentation of the skin, heterochromia irides, deafness, and Hirschsprung disease) [28,29]. This evidence concerns the gene SOX10 and hypopigmentation of the skin.