Besides, PRAME is expressed in many other tumors (germ cell tumors of the testis, lymphomas, peripheral nerve sheath tumors, ovarian carcinomas, etc.)but not in the majority of desmoplastic cM (one of the most challenging melanocytic lesions), and we already suggested great caution before the adoption of PRAME as a “pan-melanoma” marker [96,97,98,99,100,105,106,107]. The gene discussed is PRAME; the disease is lymphoma.