Although, in the 2018 WHO Classification of Skin Tumors, Ki67 is strongly recommended for the differential diagnosis between dysplastic cN (<5%) and superficial spreading cM (>30%); in our personal experience, it is quite impossible to find “early” superficial spreading cM (those that raise more diagnostic problems with dysplastic cN) with such high Ki67 [7,8]. This evidence concerns the gene MKI67 and skin neoplasm.