iNKT cells have the capacity to mediate direct cytolytic activity against CD1d positive tumor cells via perforin and granzyme B. Even if the majority of solid tumors are CD1d-negative, iNKT cells can suppress tumor growth indirectly by targeting CD1d-positive elements of tumor-supportive stroma, such as tumor-associated macrophages [5]. Here, CD1D is linked to neoplasm.